The aim of the present project is to establish 3-dimensional human cultures for predicting interactions between material and tissue. The long-term goal is to develop novel alloys and sponge-like structures to establish an artificial bone marrow niche, including the production of cellular blood components.

The aim of the present project is to develop perfusion units including sensors. In these bioreactors complex tissue models, especially of the thorax, must be cultured and characterized non-invasively. After the technology has been standardized, relevant biomarkers will be identified in the long term to enable co-evolution between tissue and implant. The challenge lies in the development of intelligent implants that react to environmental factors in the sense of co-evolution, for example with the release of steroids in the event of inflammation.